If you're looking for a fun theme with an artistic style, this one for HTC Sense (with Co0kie's home tab), which is based on Mattahan's popular art and icons, may be the perfect fit for you. Some skin-makers (Degake, Rawrscary, Sniper-wolf, Rurph, Franwella) at XDA-developers have teamed up to create a Buuf theme using custom icons, wallpaper, clocks (analog/digital), notifications, sliders and more. They're calling it a "BUUFfet" because you can mix and match the skins you want while they pump out more and more choices.
I've seen similar themes on various platforms, so it's nice to see one make its way to Sense 2.5. Check out the video below to see it in action and get the files from XDA-developers (WVGA). They're taking requests for custom icons, so feel free to ask them.
Notes: should you decide to uninstall any parts of the theme, make sure to disable Sense first. Also, it's always a good idea to backup your files before applying any tweaks or mods. Some skins aren't shown in the video or post, so check out the XDA thread if you're interested.