On a TouchFLO 3D powered device, such as the Touch Diamond, Touch Pro or Touch HD (and variants), you can easily customize your shortcuts in the Programs tab, by adding/modifying/removing items.

There’s a way you can lock your shortcuts so you won’t accidentally delete or modify them. In order to lock a slot, you need to edit your registry by navigating to: HKEY_LOCAL_MACHINESoftwareHTCManilaProgramLauncher

There you will see 24 numbered folders from 0 to 23. Each one of them has a correspondent in a slot at the Programs tab, so that 0 will be the first one and 23 the last one. In order to lock a slot, enter the corresponding key folder (say key folder 0 for slot 1) and edit the value of IsReadOnly from 0 to 1. You will no longer be able to modify the shortcut on slot 1 within the Programs tab on TouchFLO 3D.

Unlocking – as described by XDA Developers – follows the same procedure, only you need to change the value of IsReadOnly from 1 to 0.